Уважаемые коллеги, доброго времени суток! Представляем вам японское научное издание Regenerative Therapy. Журнал имеет второй квартиль, издается в Japanese Society of Regenerative Medicine, находится в открытом доступе, его SJR за 2020 г. равен 0,726, импакт-фактор - 3,419, электронный ISSN - 2352-3204, предметные области - Биомедицинский инжиниринг, Биоматериалы, Онтогенетика (биология развития). Вот так выглядит обложка:
Редактором является Унг - ил Чунг, контактные данные - tei@bioeng.t.u-tokyo.ac.jp.
Это официальный рецензируемый онлайн-журнал Японского общества регенеративной медицины. Regenerative Therapy - междисциплинарный журнал, в котором публикуются оригинальные статьи и обзоры фундаментальных исследований, клинических переводов, промышленных разработок и вопросов регулирования, посвященных биологии стволовых клеток, тканевой инженерии и регенеративной медицине.
Адрес издания - https://www.sciencedirect.com/journal/regenerative-therapy
Пример статьи, название - Therapeutic effects of asperosaponin VI in rabbit tendon disease. Заголовок (Abstract)
Introduction
This study explored the effects and molecular mechanisms of asperosaponin VI in tendon disease.
Methods
Forty-eight purebred adult male New Zealand white rabbits were randomly divided into the normal group (normal, n = 8); saline group (saline, n = 8) and prostaglandin E2 group (n = 32), which was further divided into four subgroups that were treated with asperosaponin VI doses of 0 mg/kg (model, n = 8), 10 mg/kg (10, n = 8), 20 mg/kg (20, n = 8) and 40 mg/kg (40, n = 8). The expression levels of matrix metallopeptidase 1 (MMP1), metallopeptidase inhibitor 1 (TIMP1), transforming growth factor beta 1 (TGFB1), serpin family E member 1 (SERPINE1), collagen Ⅰ (COL1), collagen Ⅲ (COL3) and tenomodulin (TNMD) in Achilles tendon tissue were determined through Western blot analysis. The histopathological changes in tendon tissue were observed by using Masson staining and haematoxylin–eosin staining.
Results
The expression levels of MMP1, TIMP1 and COL3 were higher and those of TGFB1, SERPINE1, COL1 and TNMD were lower in the 0 mg/kg group than in the normal group (P < 0.05). Compared with those in the 0 mg/kg group, the levels of MMP1 were lower in the 20 and 40 mg/kg groups. Compared with those in the 0 mg/kg group, the levels of TIMP1 were lower and the levels of TGFB1, COL1 and TNMD were higher in the 10, 20 and 40 mg/kg groups. In addition, compared with those in other groups, the levels of SERPINE1 in the 40 mg/kg group were significantly higher and the levels of COL3 in the 10 and 20 mg/kg groups were significantly lower (P < 0.05). Fibrous tissue arrangements and structures in the 40 mg/kg group were similar to those in the control group.
Conclusion
The effects of asperosaponin VI on injured tendons mainly involve eliminating inflammation, restoring balance to extracellular matrix collagen metabolism and inducing tendon cell proliferation. Asperosaponin VI is likely to be an ideal drug for the prevention and treatment of tendon disease.
Keywords: Asperosaponin Ⅵ; Achilles tendon disease; Healing; Collagen; Proliferation; Fibrosis
