https://reader.elsevier.com/reader/sd/pii/S2589909020300186?token=9A4AA65D4A7EDFF003CBD361EC1ADD6F3DF1B6AE0331881D4D42243E3F37AF
Highlights
•All SARS-CoV-2 immunogenic epitopes have similarity to human proteins except one.•Roughly one-third of the potentially targeted human proteins (putative autoantigens) are key players in the adaptive immune system.
•The list of viral/human protein matches
Highlights
•All SARS-CoV-2 immunogenic epitopes have similarity to human proteins except one.•Roughly one-third of the potentially targeted human proteins (putative autoantigens) are key players in the adaptive immune system.
•The list of viral/human protein matches provides clues on which epitopes or parts of epitopes might be involved in the immunopathogenesis of COVID-19 disease from SARS-CoV-2 infection.
•It also indicates which epitopes might be responsible for autoimmunological pathogenic priming due to prior infection or following exposure to SARS-CoV-2 or relatives following vaccination.
•These epitopes should be excluded from vaccines under development to minimize autoimmunity due to risk of pathogenic priming.
