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Melanoma .

First , ultraviolet radiation changes physically chemical properties of melanin . Aggressive form of such moleculars has ability to make trigger of mitosis and this would be some pathology mitosis - atypical . There's a lot of vessels into birthmark . Wall of vessels has pigment , and aggressive melanin is getting to cells of vessels as pigment , but with triggering patalogic mitosis . And atipical mitotic cells would be floating to any part of organism and make metastasis .
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