💊 Sildenafil for Erectile Dysfunction: Evidence‑Based Dosing, Indications, and Management Across the Lifespan

💊 Sildenafil for Erectile Dysfunction: Evidence‑Based Dosing, Indications, and Management Across the Lifespan

Erectile dysfunction (ED) affects ≈ 30 % of men aged 40–49 years and ≈ 70 % of men ≥ 70 years, imposing a $9.6 billion annual US health‑care burden. Sildenafil restores erection by inhibiting phosphodiesterase‑5 (PDE5), amplifying cyclic GMP signaling in penile smooth muscle. Diagnosis hinges on …

📌 Key Points

📌 Overview and Epidemiology

📌 Pathophysiology

📌 Clinical Presentation

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