Уважаемые коллеги, доброго времени суток! Представляем вам французское научное издание Journal of Drug Delivery Science and Technology. Журнал имеет первый квартиль, издаётся в Editions de Sante, его SJR за 2022 г. равен 0,688, импакт-фактор 5, печатный ISSN - 1773-2247, электронный - 2588-8943, предметная область Фармацевтические науки. Вот так выглядит обложка:
Редактором является Флоренс Сипманн, контактные данные - florence.siepmann@univ-lille.fr.
Это международный журнал, посвященный доставке лекарств и фармацевтическим технологиям. Он освещает все инновационные аспекты всех фармацевтических лекарственных форм и самые передовые исследования в области контролируемого высвобождения, биодоступности и абсорбции лекарств, наномедицины, доставки генов, тканевой инженерии и т.д. Также приветствуются актуальные темы, связанные с производственными процессами и контролем качества.
Адрес издания - https://www.sciencedirect.com/journal/journal-of-drug-delivery-science-and-technology
Пример статьи, название - Structural modifications for the conversion of proteins and peptides into stable dried powder formulations: A review. Заголовок (Abstract) -The drying of biomolecules into powdered formulations has become the main form of long-term product stabilisation, allowing for the delivery of safe and efficient medicines. Stability of proteins and peptides during the drying process is paramount for product quality. Drying macromolecules with an appropriate excipient is often sufficient for product stabilisation, however there are limitations imposed on excipient use, particularly in the production of high-value biopharmaceuticals. Innovative approaches for the enhancement of protein stability during dehydration need to be further explored. In this review, we provide a brief discussion of the available drying methods and current stabilisation techniques available for proteins and peptides and review the current impact and limitations of excipient use. Alongside, we take a detailed look at the impact of post-translational modifications (PTMs) and structural mutations in drying stability of biomolecules. The structural modifications mentioned in this paper are discussed in light of published work on their impact on protein and peptide stability during commonly experienced stresses, particularly those which relate to drying processes, such as chemical, thermal and freeze-thaw. The aim of this review is to direct a research focus towards upstream modifications of proteins and peptides as a viable stabilisation approach during harsh drying processes.
Graphical abstract
Keywords: Biological formulations; Protein and peptide stability; Protein engineering; Post-translational modifications; Polymer conjugation; Structural modifications