Уважаемые коллеги, доброго времени суток! Представляем вам австрийское научное издание Journal für Reproduktionsmedizin und Endokrinologie. Журнал имеет четвёртый квартиль, издаётся в Krause und Pachernegg GmbH., его SJR за 2022 г. равен 0,125, печатный ISSN - 1810-2107, электронный - 1810-9292, предметные области - Репродуктивная медицина, Эндокринология, диабет и метаболизм, Родовспоможение и гинекология. Вот так выглядит обложка:
Редактором является Херманн Бере, контактные данные - hermann.behre@medizin.uni-halle.de.
Дополнительные публикационные контакты - verena.nordhoff@ukmuenster.de, t.schill@kinderwunsch-langenhagen.de, brz@repromed.de.
Это онлайн-журнал, публикующий обзоры и статьи о дальнейшем образовании во всех областях репродуктивной медицины и эндокринологии.
Адрес издания - https://www.kup.at/journals/reproduktionsmedizin/
Пример статьи, название - Human chorionic gonadotropin; hCG) – an important multifunctional hormone of reproduction. Заголовок (Abstract) - Human chorionic gonadotropin; hCG) – an important multifunctional hormone of reproduction. The peptide-hormone chorionic gonadotropin (CG) exists only in higher primates and humans (human chorionic gonadotropin; hCG). The molecule is formed by a point mutation of the gene coding for the luteinizing hormone (LH) in mammals. The prolonged half-life of hCG (36.7 hours) compared to the LH (25 minutes) and its stronger binding activity to the LH/hCG receptor leads to an altered biological activity. hCG has a potency about 50 times higher than LH.
Five hCG isoforms (regular hCG, sulfated hCG, hyperglycosylated hCG, the free beta subunit of hCG, the hyperglycosylated free beta subunit of hCG) with different functions have been identified until now.
During the reproductive process the maturation of oocytes is essentially controlled by two hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH primarily promotes the growth of follicles, while LH supports the maturation of oocytes. With regard to the maturation of oocytes a distinction is made between nuclear and cytoplasmic maturation. Studies demonstrate that during the menstrual cycle, another gonadotropin – hCG – is secreted pulsatile in the pituitary gland and is involved in follicular and oocyte maturation processes. As part of controlled ovarian stimulation hCG, rLH and GnRH agonists have been used to induce final oocyte maturation. Kisspeptin is under clinical investigation and has only been used in trials. These four substances all cause preovulatory maturation of oocytes, but via different points of attack in the effect cascades of maturation induction. Different results - especially concerning the risk for OHSS (ovarian hyperstimulation syndrome) development are the consequence. The LH activity unfolded by the hCG molecule is characterized by a longer half-life and stronger biological activity than that of the original LH molecule. The use of hCG in reproductive medicine therefore leads to a longer LH activity exposure and thus prevents a dysfunctional luteal phase even after only a single administration. Till today hCG remains the „gold standard“ for stimulating oocyte maturation. Alternative triggers for oocyte maturation induction such as kisspeptin and rLH could gain importance in the future. In addition to oocyte maturation hCG also plays an important role during implantation, immunological protection of the embryo and pregnancy maintenance. Furthermore, it serves as a diagnostic marker for cancers such as germ cell tumours of the testis and ovary. J Reproduktionsmed Endokrinol 2023; 20 (2): 63–75.
Key words: human chorionic gonadotropin (hCG), luteinizing hormone (LH), OHSS (ovarian hyperstimulation syndrome), GnRH agonist, Kisspeptin, oocyte maturation, implantation, luteal phase