Уважаемые коллеги, доброго времени суток! Мы начинаем обзор изданий в области Ингаляций и респираторной медицины. Сегодня хотим представить вашему вниманию нидерландское научное издание Journal of Cystic Fibrosis. Журнал имеет первый квартиль, издается в Elsevier, его SIR за 2022 г. равен 1,747, пятилетний импакт-фактор 5,527, печатный ISSN - 1569-1993, электронный - 1873-5010, предметные области - Ингаляции и респираторная медицина, Педиатрия и детское здоровье. Вот так выглядит обложка:
Редактором является Патрик Флуме, контактные данные - flumepa@musc.edu, BellS@health.qld.gov.au.
Это официальный журнал Европейского общества по муковисцидозу. Журнал посвящен популяризации исследований и лечения муковисцидоза. С этой целью к публикации принимаются оригинальные научные статьи, передовицы, клинические случаи, краткие сообщения и другая информация, имеющую отношение к муковисцидозу. Журнал также публикует новости и статьи, касающиеся деятельности и политики ECFS и других обществ, связанных с ECFS.
Адрес издания - https://www.cysticfibrosisjournal.com/
Пример статьи, название - Automatic bronchus and artery analysis on chest computed tomography to evaluate the effect of inhaled hypertonic saline in children aged 3-6 years with cystic fibrosis in a randomized clinical trial. Заголовок (Abstract)
Background
SHIP-CT showed that 48-week treatment with inhaled 7% hypertonic saline (HS) reduced airway abnormalities on chest CT using the manual PRAGMA-CF method relative to isotonic saline (IS) in children aged 3-6 years with cystic fibrosis (CF). An algorithm was developed and validated to automatically measure bronchus and artery (BA) dimensions of BA-pairs on chest CT. Aim of the study was to assess the effect of HS on bronchial wall thickening and bronchial widening using the BA-analysis.
Methods
The BA-analysis (LungQ, version 2.1.0.1, Thirona, Netherlands) automatically segments the bronchial tree and identifies the segmental bronchi (G0) and distal generations (G1-G10). Dimensions of each BA-pair are measured: diameters of bronchial outer wall (Bout), bronchial inner wall (Bin), bronchial wall thickness (Bwt), and artery (A). BA-ratios are computed: Bout/A and Bin/A to detect bronchial widening and Bwt/A and Bwa/Boa (=bronchial wall area/bronchial outer area) to detect bronchial wall thickening.
Results
113 baseline and 102 48-week scans of 115 SHIP-CT participants were analysed. LungQ measured at baseline and 48-weeks respectively 6,073 and 7,407 BA-pairs in the IS-group and 6,363 and 6,840 BA-pairs in the HS-group. At 48 weeks, Bwt/A (mean difference 0.011; 95%CI, 0.0017 to 0.020) and Bwa/Boa (mean difference 0.030; 95% 0.009 to 0.052) was significantly higher (worse) in the IS-group compared to the HS-group representing more severe bronchial wall thickening in the IS-group (p=0.025 and p=0.019 respectively). Bwt/A and Bwa/Boa decreased and Bin/A remained stable from baseline to 48 weeks in the HS while it declined in the IS-group (all p<0.001). There was no difference in progression of Bout/A between two treatment groups.
Conclusion
The automatic BA-analysis showed a positive impact of inhaled HS on bronchial lumen and wall thickness, but no treatment effect on progression of bronchial widening over 48 weeks.
Keywords: Cystic fibrosis; Structural airway disease; Hypertonic saline; Bronchial wall thickening; Artificial intelligence; Computed tomography