Уважаемые коллеги, доброго времени суток! Представляем вам тайваньское научное издание Taiwanese Journal of Obstetrics and Gynecology. Журнал имеет третий квартиль, издаётся в Elsevier Taiwan LLC, находится в открытом доступе, его SJR за 2021 г. равен 0,413, импакт-фактор 1,944, электронный ISSN - 1028-4559, предметная область Родовспоможение и гинекология. Вот так выглядит обложка:
Редактором является Ши-Уан Чен, контактные данные - sheeuan@ntu.edu.tw.
Это рецензируемый журнал с открытым доступом, публикующий передовицы, обзоры, оригинальные статьи, краткие сообщения, тематические отчеты, исследовательские письма, корреспонденцию и письма в редакцию в области акушерства и гинекологии. Целями журнала являются:
1. Публикация передовых, инновационных и актуальных исследований, касающихся скрининга, диагностики, ведения и ухода за здоровьем женщин;
2. Предоставление информации, основанной на фактических данных;
3.Содействие обмену клиническим опытом;
4. Решение вопросов укрепления здоровья женщин.
Журнал обеспечивает всестороннее освещение по темам акушерства и гинекологии и женского здоровья, включая медицину матери и плода, репродуктивную эндокринологию/бесплодие и гинекологическую онкологию. Он выходит при поддержке Тайваньской ассоциации акушерства и гинекологии.
Адрес издания - https://www.sciencedirect.com/journal/taiwanese-journal-of-obstetrics-and-gynecology
Пример статьи, название - The effect of carvacrol on the proinflammatory cytokines, histology, and fertility outcome of cisplatin-related ovarian change in a rat model. Заголовок (Abstract)
Objective
In women, agents used in chemotherapy treatment have side effects such as accelerating follicular depletion and early menopause. Thus, cytotoxic treatments may cause various effects ranging from partial damage to the ovary to premature ovarian failure (POI) and infertility.
This study aimed to investigate the protective effect of carvacrol on cisplatin (CIS)-induced reproductive toxicity in female rats.
Materials and methods
The animals were divided to four groups; a healthy group (HG), administered only cisplatin 2.5 mg/kg (CIS); cisplatin 2.5 mg/kg + carvacrol mg/kg (CC-50), and cisplatin 2.5 mg/kg + carvacrol 100 mg/kg (CC-100). In this study, the CC-50 and CC-100 groups were injected with carvacrol at 50 and 100 mg/kg intraperitoneally (IP). The CIS and HG groupswere administered normal saline as a solvent in the same way. One hour afterwardthe CC-50 and CC-100 groups were injected with cisplatin at 2.5 mg/kg IP. This procedure was continued once a day for 14 days. At the end of this period, six rats from each group were euthanized with high-dose anaesthesia. Biochemical (oxidant-antioxidant and proinflammatory cytokines) and histopathological examinations were performed on the right ovarian tissue removed from the dead rats. The remaining (n = 6 in each group) animals were kept in the laboratory with mature male rats for two months for breeding. Rats that didn't give birth within two months were considered infertile. A one-way ANOVA test was used for the biochemical analysis, the a Kruskal Wallis test was used for the histopathological analysis.
Results
It has been observed that cisplatine causes oxidative stress and inflammatory damage in the ovarian tissue of animals and ultimately causes infertility due to this oxidative stress. While carvacrol significantly suppressed cisplatin-related oxidative stress in ovarian tissue at the 50 and 100 mg/kg doses, it could suppress proinflammatory cytokine increase only at thecytokine increase only at the 100 mg/kg dose. In addition, carvacrol significantly reduced the development of cisplatin-related infertility (from 0 to 83.3%) at a dose of 100 mg/kg.
Conclusion
These findings suggest that carvacrol at high doses can reduce the harmful effects of cisplatin on the ovary and improve ovarian reserve in rats.
Keywords: Carvacrol; Cisplatin; Infertility; Rat; Reproductive performance