There's risk factors of disseas : hypertension, fatness, diabetes, using of urine active drugs for a long time. There's glomeruls in rens, where is urine filtration. That's endocrine system in uksta-glomer with renin production there's for pressure filtration. But , in a case of priviesly noted risk factors , there's kathecholamins are rising in activity. Hence , pressure of filtration there are would be thanks to renin and kathecholamins. And force of this pressure would be reason of damage pors in podocytes. And there are would be cells damage a hole. Then regenerative cells mitosis would start up. But pressure in functionality of podocytes activity would stay the same. And there'll be crashing of mitotic cells with yielding of mitotic moleculars, which, penetrating into nearest cells, would miss row order of the most mitosis and that'll be reason of amitotic transfortation, so development of cancer disease