Уважаемые коллеги, доброго времени суток! Представляем вам иранское научное издание Iranian Journal of Immunology. Журнал имеет четвёртый квартиль, издаётся в Shiraz University of Medical Sciences, находится в открытом доступе, его SJR за 2021 г. равен 0,333, печатный ISSN - 1735-1383, электронный - 1735-367X, предметные области - Иммунология, Иммунология и аллергические реакции, Медицина. Вот так выглядит обложка:
Редактором является Аббас Гхадери, контактные данные - ghaderia@sums.ac.ir, mehdipourf@sums.ac.ir, malekzadem@sums.ac.ir, iji@sums.ac.ir.
Это международный рецензируемый журнал, в котором публикуется широкий спектр экспериментальных и теоретических исследований, касающихся всех аспектов иммунологии.
Адрес издания - Association Between Polymorphisms of IL-23/IL-17 Pathway and Clinical Phenotypes of Autoimmune Thyroid Diseases. Заголовок (Abstract)
Background: Several autoimmune and inflammatory disorders, including autoimmune thyroid diseases (AITD), have been linked to Th17 cells and the IL-23/IL-17 axis. Current data suggest that genetic variation contributes greatly to disease susceptibility to AITD. Objectives: To study the role of single nucleotide polymorphisms (SNPs) of IL-23/IL-17 pathway in AITD predisposition and test the gene-gene/gene-sex interactions in these loci. Methods: A total of 1051 patients with AITD, including 657 patients with Graves' disease (GD) and patients with 394 Hashimoto's thyroiditis (HT), and 874 healthy controls were enrolled in this case-control association study. Six SNPs were selected and genotyped by multiplex PCR combined with high-throughput sequencing. Interactions were tested by the general multifactor dimensionality reduction (GMDR) method. Results: Allele C and combinational genotype AC+CC of rs3212227 within il-23 significantly associated with GD with goiter (p=0.003 and 0.014, respectively). Allele G and combinational genotype AG+GG of rs4819554 within il-17ra significantly related to HT with family history and the severity of HT (p=0.011 and 0.027; p=0.041 and 0.035). Also, allele T and genotype CT+TT of rs9463772 within il-17f significantly correlated with the severity of HT (p=0.001 and 0.027, respectively). Moreover, high dimensional gene-sex interaction (il-23r-il-23-il-17ra-il-17f-sex) was identified in AITD, GD, and HT patients with GMDR analysis. Conclusions: Our study identified the novel loci and gene-sex interaction in AITD. This evidence, from another perspective, suggests that sex, IL-23/IL-17 pathway, and Th17 cells play an important role in the pathogenesis of AITD. Keywords: Autoimmune Thyroid Diseases (AITD); Gene-gene Interaction; Gene-sex Interaction; IL-23/IL-17 Pathway; Single Nucleotide Polymorphism (SNP)