Применение ГК повышает (по сравнению с теми, кто ее не использует) вероятность опасных осложнений:
- Ишемического инсульта в 3 раза (1, 2, 3)
- Тромбоза глубоких вен в 5 раз (4, 5)
- Легочной эмболии в 3 раза (4)
- Инфаркта миокарда в 2 раза (6)
- Тромбоза венозного синуса твёрдой мозговой оболочки в 7,6 раза (1, 7, 8, 9)
- Рака молочной железы в 1,44−4,2 раза в зависимости от типа РМЖ (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- Рака шейки матки в 2−3 раза в зависимости от длительности приема (11, 12, 20, 21, 22, 23)
- Рака печени в 1,5 раза (11, 12, 24)
- Психических нарушений (депрессия, панические атаки и др.) в 1,7 раза (25, 26)
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14) Zhu H, Lei X, Feng J & Wang Y. (2012). Oral contraceptive use and risk of breast cancer: A meta-analysis of prospective cohort studies. The European Journal of Contraception & Reproductive Health Care, 17:6, pp. 402-414. Источник URL: https://www.tandfonline.com/doi/abs/10.3109/13625187.2012.715357?journalCode=iejc20
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17) Liu Yu-hong. (2011). Investigation and Analysis of Risk Factors of Breast Cancer of Women. Modern Preventive Medicine. Источник URL: http://en.cnki.com.cn/Article_en/CJFDTOTAL-XDYF201103027.htm
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21) Appleby P, Beral V, Berrington de González A, Colin D, Franceschi S, Goodhill A, et al. (2007). Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet, Vol. 370 (9599), pp. 1609–1621. Источник URL: https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(07)61684-5
22) Smith JS, Green J, Berrington de Gonzalez A, et al. Cervical cancer and use of hormonal contraceptives: a systematic review. Lancet, 2003; Vol. 361, Issue 9364: pp. 1159–1167. Источник URL: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)12949-2
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24) Рак печени (печеночноклеточный). Клинические рекомендации. 2017 г. Ассоциация онкологов России совместно с Российским обществом клинических онкологов. Министерство Здравоохранения РФ. Источник URL: http://oncology-association.ru/files/clinical-guidelines_adults/rak_pecheni.pdf
25) Skovlund CW, Mørch LS, Kessing LV, Lidegaard Ø. (2016). Association of Hormonal Contraception With Depression. JAMA Psychiatry; Vol. 73 (11): pp. 1154–1162. Источник URL: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2552796?rel=1
26) Skovlund C. W., Mørch L. S., Kessing L. V., Lange T., Lidegaard Ø. (2018). Association of Hormonal Contraception With Suicide Attempts and Suicides. American Journal of Psychiatry, Vol. 175:4, 336–342. Источник URL: https://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.2017.17060616