Уважаемые коллеги, доброго времени суток! Представляем вам швейцарское научное издание European Cells and Materials. Журнал имеет второй квартиль, издается в AO Research Institute, находится в открытом доступе, его SJR за 2019 г. равен 1,141, печатный ISSN - 1473-2262, предметные области - Биохимия, Биоматериалы, Биомедицинский инжиниринг, Клеточная биология (цитология). Вот так выглядит обложка:
Редактором является Джеоф Ричардс, контактные данные - geoff.richards@aofoundation.org, ecm@aofoundation.org, iolo.apgwynn@gmx.com
Целью издания является обеспечение междисциплинарного форума для публикации доклинических исследований в области опорно-двигательного аппарата (Ортопедия, Травматология, Челюстно-лицевая хирургия, в том числе стоматологическая и Позвоночник). Материалы о клинических случаях или серии подобных случаев к публикации не принимаются. Журнал издается в научно-исследовательском институте Давоса, некоммерческой организации в Швейцарии.
Пример статьи, название - Sintered S53P4 bioactive glass scaffolds have anti-inflammatory properties and stimulate osteogenesis in vitro. Заголовок (Abstract) - Bioactive glasses (BAG) are used as bone-graft substitutes in orthopaedic surgery. A specific BAG scaffold was developed by sintering BAG-S53P4 granules. It is hypothesised that this scaffold can be used as a bone substitute to fill bone defects and induce a bioactive membrane (IM) around the defect site. Beyond providing the scaffold increased mechanical strength, that the initial inflammatory reaction and subsequent IM formation can be enhanced by coating the scaffolds with poly(DL-lactide-co-glycolide) (PLGA) is also hypothesised. To study the immunomodulatory effects, BAG-S53P4 (± PLGA) scaffolds were placed on monolayers of primary human macrophage cultures and the production of various pro- and anti-inflammatory cytokines was assessed using reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) and ELISA. To study the osteogenic effects, BAG-S53P4 (± PLGA) scaffolds were cultured with rabbit mesenchymal stem cells and osteogenic differentiation was evaluated by RT-qPCR and matrix mineralisation assays. The scaffold ion release was quantified and the BAG surface reactivity visualised. Furthermore, the pH of culture media was measured. BAG-S53P4 scaffolds had both anti-inflammatory and osteogenic properties that were likely attributable to alkalinisation of the media and ion release from the scaffold. pH change, ion release, and immunomodulatory properties of the scaffold could be modulated by the PLGA coating. Contrary to the hypothesis, the coating functioned by attenuating the BAG surface reactions and subsequent anti-inflammatory properties, rather than inducing an elevated inflammatory response compared to BAG-S53P4 alone. These results further validated the use of BAG-S53P4 (± PLGA) scaffolds as bone substitutes and indicate that scaffold properties can be tailored to a specific clinical need. Key Words: Bioactive glass, S53P4, PLGA, anti-inflammatory, osteogenesis stimulation.