There is desodering in salt and microelements regulation as pielonephritis is developed in organism. Result of that is in cumulation of Fe, MG, Cu in tissue. These are part of ferments of tissue so as peroxidasa and citochromoxidasa . There is a lot of that produced, then usually and its activity destroying cells wall in a place where is cholesterol. There is intermedation with, thanks to which is testosterone ( peroxidasa) and degidroandrostendinol ( cytochromoxidasa ) . Two sex hormones in unusual place with pathology circumstances- pielonephritis. Cumulation of these hormones into cells would be triggering mitosis, as in spermatogenesis proper be in normal condition, but pathological initiation in cells apart of sex organs would make desodering in cells dividing, because mayos in spermatogenesis isn't diploid mitosis in suffered tissue. And that'll be atypical cancer cells as a result. Reason of cancer is established!